Proton Pump Inhibitors or PPI meds side effects in the long term can lead to serious kidney problems, including kidney failure. PPI meds also used to treat stomach ulcers because it can reduce stomach acid by inhibiting the formation of acid in a long time. This study evaluated the use of PPIs on 125,000 patients who prove that more than half of the patients had chronic kidney damage. When using these drugs, they do not experience acute kidney problems first, patients may not aware of decreased kidney function. People using heartburn medication containing PPI should be more alert, and physicians should better monitor the use of these drugs.