Scientists may be a breakthrough in developing the septic shock treatment, subcutaneous injection of Orexin Neuropeptides improve survival rate. Orexin was first discover by Yanagisawa and his colleagues in 1998. Orexin plays an important role for controlling sleeping or awake, and known to alter heart rate and body temperature in rats. This proves that orexin has the potential to be a therapeutic agent for circulatory shock. But clinically, orexin known to be difficult because it reacts in the brain, and the delivery of orexin molecules to the brain blocked by a blood-brain barrier (BBB). Carrier molecule required collective and separate it from the circulatory system to protect the central nervous system (CNS) of hazardous substances.